SYNTHETIC ROUTE DISCOVERY AND SELECTION

For a new chemical entity and/or for an existing substance the choice of the "best" synthetic route is carefully evaluated at the very beginning of the project with a thorough feasibility study:

  • Likelihood of success related to the robustness of the chemistry selected
  • Availability, cheapness, number of suppliers for raw materials
  • Number of steps and ease of scale up
  • Selectivity.

Enviromental impact and safety. The use of highly toxic raw materials and reagents, or the likelihood of explosion hazards during scale up, may make a route unattractive.
A balance of factors and the results of the first experiments are obtained and a reiterative evaluation of the route must be done.

Custom Synthesis

The SERICHIM lab offers pilot structures, which allow working up to a level of a few hundred liters in a large range of operative conditions. The most important of the existing equipment :

  • Glass-lined and stainless-steel reactors with a capacity up to 500 liters
  • High temperature reactor (up to 300° C)
  • 20 theoretical plate batch glass-lined distillation column
  • filters, centrifuges and drying equipment
  • acompletely segregated large walk-in fume hood, equipped with a scrubber to treat the expelled air, catching contaminants incidentally released.

Parallel Synthesis

Parallel synthesis is a strategy to optimize the time needed to identify a set of independent variables that satisfy given constraints and the time needed to prepare products with minor differences in their structures, using the same chemistry.
In SERICHIM several parallel synthesis equipment of different complexity are available:

  • heated platform with 6 magnetically stirred 250 ml flasks;
  • heated platform with 12 magnetically stirred 100 ml tubular reactors;
  • ASW platform: a computer-controlled platform with up to 64 stirred reactors, an operative temperature range from -20 to 100°C, interfaced with HPLC chromatography for on-line analytical monitoring of the whole set of reactions.
analysis

SERICHIM S.r.l. - Piazzale Marinotti 1 - 33050 Torviscosa (UD) - Italy
Tel. +39 0431 381403 - Fax +39 0431 381400 - info@serichim.it
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